Gracias a Dios Mezcal is entirely handmade in Santiago Matatlán, Oaxaca, at the company's palenque [NOM-0223X], or distillery. Gracias a Dios Mezcal is made under the watchful eye of Maestro Mezcalero Oscar Hernández Santiago.

In this expression, the mezcal is made from tobalá agaves (agave potatorum) that grow wild in the Sierra Madre Mountains, one of many different varieties of agave native to the area.

The agaves are USDA and EU certified organic, meaning they were grown without the use of pesticides or synthetic fertilizers. The end result is a cleaner finished spirit. For each bottle the distillery produces, they plant 3 new agaves to take its place.